Overview

  • Product name

    GW 9662, PPARgamma antagonist
  • Description

    Selective PPARγ antagonist
  • Biological description

    Selective PPARγ antagonist (IC50 values are 3.3, 32, >1000 nM for PPARγ, PPARα and PPARδ respectively). Apoptotic and antimetastatic activity in vitro.
  • Purity

    > 99%
  • CAS Number

    22978-25-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang D  et al. Peroxisome proliferator-activated receptor d confers resistance to peroxisome proliferator-activated receptor ?-induced apoptosis in colorectal cancer cells. Oncogene 31:1013-23 (2012). Read more (PubMed: 21765467) »
  • Grommes C  et al. The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells. J Pharmacol Exp Ther 313:806-13 (2005). Read more (PubMed: 15665144) »
  • Leesnitzer LM  et al. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41:6640-50 (2002). Read more (PubMed: 12022867) »
See all 3 Publications for this product

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