Key features and details
- Rabbit polyclonal to GW182
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-GW182 antibody
See all GW182 primary antibodies
DescriptionRabbit polyclonal to GW182
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
A 16 amino acid peptide from near the C terminal residues of human GW182 protein (NM_020847; Q8NDV7).
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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FormLyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityProtein A purified
FunctionPlays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.
Sequence similaritiesBelongs to the GW182 family.
Contains 1 RRM (RNA recognition motif) domain.
Cellular localizationCytoplasm > P-body. Mammalian P-bodies are also known as GW bodies.
- Information by UniProt
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ab84403 has been referenced in 3 publications.
- Su W et al. miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways. Oncogene N/A:N/A (2018). PubMed: 29907771
- Aqil M et al. The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference. PLoS One 8:e74472 (2013). PubMed: 24023945
- Chen S et al. Ago-2-Mediated Slicer Activity Is Essential for Anti-Flaviviral Efficacy of RNAi. PLoS One 6:e27551 (2011). WB ; Human . PubMed: 22102908