Key features and details
- Selective cFMS RTK inhibitor. Cell-permeable.
- CAS Number: 870483-87-7
- Purity: > 99%
- Supplied in DMSO (10 mM)
- Form / State: Solid
- Source: Synthetic
Product nameGW2580 (DMSO solution), cFMS RTK inhibitor
DescriptionSelective cFMS RTK inhibitor. Cell-permeable.
Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.
Also available as a solid (ab142096).
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSupplied in DMSO (10 mM)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146624 has not yet been referenced specifically in any publications.