GW542573X, KCa2 channel activator (ab120502)
- Datasheet
- References
Overview
-
Product name
GW542573X, KCa2 channel activator -
Description
Novel, selective KCa2 channel activator -
Biological description
Novel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1. -
Purity
> 99% -
General notes
Supplied in ethanol (25 mg/ml). Please note this compound is unstable as the solid form and unstable in DMSO
-
CAS Number
660846-41-3 -
Chemical structure
Properties
-
Chemical name
4-(2-Methoxyphenylcarbamoyloxymethyl)piperidine-1-carboxylic acid tert-butyl ester -
Molecular weight
364.44 -
Molecular formula
C19H28N2O5 -
PubChem identifier
24885053 -
Storage instructions
Store at +4°C (desiccating conditions). -
Solubility overview
Supplied in ethanol (25 mg/ml) -
Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
COc2ccccc2NC(=O)OCC1CCN(CC1)C(=O)OC(C)(C)C -
Source
Synthetic
-
Research areas
References
This product has been referenced in:
- Balut CM et al. Immunofluorescence-based assay to identify modulators of the number of plasma membrane KCa3.1 channels. Future Med Chem 2:707-13 (2010). Read more (PubMed: 20596245) »
- Hougaard C et al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol 76:569-78 (2009). Read more (PubMed: 19515965) »
