GYKI 53655 hydrochloride (mM/ml), AMPA / kainate receptor antagonist (ab144499)

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Overview

  • Product name

    GYKI 53655 hydrochloride (mM/ml), AMPA / kainate receptor antagonist

  • Description

    Non-competitive AMPA / kainate receptor antagonist. 1 ml water soluble pack.

  • Alternative names

    • LY300168

  • Biological description

    Non-competitive AMPA and kainate receptor antagonist. (IC50 values for inhibition of AMPA-mediated responses in cells expressing human GluR1 and GluR4 are 6 and 5 µM, respectively). Analog of GYKI 52466 (ab120336). Anticonvulsant in vivo. At higher concentrations blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM).

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

  • Purity

    > 99%

  • CAS Number

    143692-48-2

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

  • Molecular weight

    388.85

  • Molecular formula

    C19H20N4O3.HCl

  • PubChem identifier

    126757

  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in 1ml of water to give specified mM/ml concentration

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Nc1ccc(cc1)C3=NN(C(C)Cc2cc4OCOc4cc23)C(=O)NC

  • Source

    Synthetic

  • Research areas

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References

Publishing research using ab144499? Please let us know so that we can cite the reference in this datasheet.

ab144499 has been referenced in 3 publications.

  • Kosillo P  et al. Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex N/A:N/A (2016). PubMed: 27566978
  • Chamberlain SE  et al. Long-term depression of synaptic kainate receptors reduces excitability by relieving inhibition of the slow afterhyperpolarization. J Neurosci 33:9536-45 (2013). PubMed: 23719820
  • Chamberlain SE  et al. SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity. Nat Neurosci 15:845-52 (2012). PubMed: 22522402

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