Overview

  • Product name

    H-89, PKA inhibitor
  • Description

    Potent, cell-permeable PKA inhibitor
  • Biological description

    Potent, cell-permeable PKA inhibitor (IC50 values are 0.14, 0.08, 0.12, 0.27, 2.6, and 2.8 µM for PKA, S6K1, MSK1, ROCK-II, PKBα, and MAPKAP-K1b respectively). Shows anti-addictive effects in vivo.
  • CAS Number

    127243-85-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-[[(E)-3-(4-Bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
  • Molecular weight

    446.36
  • Molecular formula

    C20H20BrN3O2S
  • PubChem identifier

    449241
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xin W  et al. Constitutive PKA activity is essential for maintaining the excitability and contractility in guinea pig urinary bladder smooth muscle: role of the BK channel. Am J Physiol Cell Physiol 307:C1142-50 (2014). Read more (PubMed: 25318105) »
  • Alamdary SZ  et al. Dual contradictory effect of H-89 on neuronal retraction, death and inflammation in differentiated PC12 cells subjected to oxidative stress. J Mol Neurosci 51:1030-7 (2013). Read more (PubMed: 23949609) »
  • Lochner A & Moolman JA The many faces of H89: a review. Cardiovasc Drug Rev 24:261-74 (0). Read more (PubMed: 17214602) »
See 1 Publication for this product

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