H 9 dihydrochloride, Protein kinase inhibitor (ab146132)

Overview

  • Product name

    H 9 dihydrochloride, Protein kinase inhibitor
  • Description

    Protein kinase inhibitor
  • Biological description

    Protein kinase inhibitor (Ki values are 0.9 (PKG), 1.9 (PKA), 18 (PKC), 60 (CaMK II), 110 (casein kinase I) and >300 μM (casein kinase II)) similar to H8 dihydrochloride (ab142309) and H7 (ab142308). Inhibits CTL-mediated lysis in vivo.
  • Purity

    > 99%
  • CAS Number

    116700-36-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride
  • Molecular weight

    324.22
  • Molecular formula

    C11H13N3O2S.2HCl
  • PubChem identifier

    11957465
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN.Cl.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Boyer JC  et al. Calcitonin gene-related peptide-induced relaxation of isolated human colonic smooth muscle cells through different intracellular pathways. Biochem Pharmacol 56:1097-104 (1998). Read more (PubMed: 9802318) »
  • Hidaka H & Kobayashi R Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32:377-97 (1992). Read more (PubMed: 1605572) »
  • Juszczak RJ & Russell JH Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors. Evidence for the involvement of protein kinase C in lymphocyte function. J Biol Chem 264:810-5 (1989). Read more (PubMed: 2783420) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146132.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up