Key features and details
- Rabbit polyclonal to H-ERG
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-H-ERG antibody
See all H-ERG primary antibodies
DescriptionRabbit polyclonal to H-ERG
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide within Human H-ERG conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: Q12809
- HeLa whole cell lysate (ab150035) and Human heart tissue
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituent: 1% BSA
Concentration information loading...
Our Abpromise guarantee covers the use of ab196301 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/250 - 1/500. Predicted molecular weight: 127 kDa.|
|IHC-P||1/50 - 1/500.|
FunctionPore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
Tissue specificityHighly expressed in heart and brain.
Involvement in diseaseDefects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:613688]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2.
Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.
Sequence similaritiesBelongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
modificationsPhosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
- Information by UniProt
- eag homolog antibody
- Eag-related protein 1 antibody
- ERG antibody
ab196301 has been referenced in 3 publications.
- Xu T et al. Anticancer effect of miR-96 inhibitor in bladder cancer cell lines. Oncol Lett 15:3814-3819 (2018). PubMed: 29467898
- Jiang Q et al. Identification of small-molecule ion channel modulators in C. elegans channelopathy models. Nat Commun 9:3941 (2018). PubMed: 30258187
- Zeng W et al. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer 7:746-57 (2016). IHC-P, WB ; Human . PubMed: 27076857