• Product name
    Anti-H2A.Z (acetyl K3 + K8 + K10 + K14) antibody
    See all H2A.Z primary antibodies
  • Description
    Sheep polyclonal to H2A.Z (acetyl K3 + K8 + K10 + K14)
  • Host species
  • Specificity
    ab43983 was raised against an acetylated N-terminal H2A.Z peptide at residues K3, K8, K10 and K14. However, it is currently unclear if the antibody recognises all of these modifications or indeed unmodified H2A.Z. Customer feedback on this matter is appreciated.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Saccharomyces cerevisiae
    Does not react with: Chicken, Cow
  • Immunogen

    Synthetic peptide corresponding to Saccharomyces cerevisiae H2A.Z aa 1-18 (N terminal) (acetyl K3 + K8 + K10 + K14).


    Database link: P0C0S5


Associated products


Our Abpromise guarantee covers the use of ab43983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 14 kDa (predicted molecular weight: 14 kDa).


  • Function
    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
  • Sequence similarities
    Belongs to the histone H2A family.
  • Post-translational
    Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
    Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.
    Not phosphorylated.
  • Cellular localization
    Nucleus. Chromosome.
  • Information by UniProt
  • Alternative names
    • H2A/z antibody
    • H2afz antibody
    • H2AZ antibody
    • H2AZ_HUMAN antibody
    • Histone H2A.Z antibody
    see all


  • Anti-H2A.Z (acetyl K3 + K8 + K10 + K14) antibody (ab43983) at 2 µg/ml + S. cerevisiae lysate at 2 µg/ml

    Predicted band size: 14 kDa


ab43983 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A


Thank you for contacting us and for your interest in our products.

Unfortunately we have yet to receieve the Abreview concerning ChIP for ab43983. All tested applications are specified on our datasheets, and these are updated as soon as any new information is brought to our attention. However, if you would like to test ab43983 in ChIP, I would be happy to give you a testing discount.

Simply follow these easy steps below to apply for our AbTrial Program:

1. Reply to this email, letting us know you are interested in testing this product.

2. Our scientists will email you an inactive personal discount code for the value of the product.

3. Purchase and test the product at the regular price.

4. Submit your results, including your discount code in the additional notes section of your Abreview.

5. Once the Abreview is submitted, the discount code will become active.

6. Apply your discount code on your next order to receive that value off.

Please let me know if you have any questions about this offer and I would be happy to help you further.

The Terms and Conditions of this offer can be found at: www.abcam.com/abtrial.

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Thank you for your call earlier this week and for your patience while I have been in touch with the lab regarding this antibody.

Unfortunately there has not been further characterization done on this antibody, so we don't have additional data to share. We look forward to receiving your Abreview once your studies are completed.

Please let me know if you have any questions or if there is anything else you might need.

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Thank you for your call today.Please see below for information about your testing discount code, and let me know if you have any questions. I'll get back to you once I have a response from the lab regarding further testing of this antibody.

Expiration date: August 25, 2012

This code will give you 1 free primary antibody before the expiration date. To redeem this offer, please submit an Abreview for ab43983 in ChIPand include this code in the “Additional Comments” section so we know the Abreview is for this promotion. For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.

The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.

Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.

The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount.

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