Overview

  • Product name

  • Description

    Rabbit polyclonal to H2R
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Hamster, Chimpanzee, Monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide within Human H2R (intracellular). The exact sequence is proprietary. ab188933 was raised against synthetic 16 amino acid peptide from 3rd cytoplasmic domain of Human H2R Receptor.
    Database link: P25021

  • Positive control

    • Human stomach, parietal cells, tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab188933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 38 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gastric receptor 1 antibody
    • Gastric receptor I antibody
    • H2R antibody
    • HGNC:5183 antibody
    • HH2R antibody
    • Histamine H2 receptor antibody
    • Histamine receptor H2 antibody
    • HRH2 antibody
    • HRH2_HUMAN antibody
    • OTTHUMP00000161242 antibody
    • OTTHUMP00000161243 antibody
    see all

Images

  • Immunohistochemical staining of Human stomach, parietal cells, tissue labeling H2R using ab188933 at 38 µg/ml.

References

ab188933 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188933.
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