Anti-H2R antibody (ab39964)
Key features and details
- Goat polyclonal to H2R
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
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Overview
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Product name
Anti-H2R antibody
See all H2R primary antibodies -
Description
Goat polyclonal to H2R -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Dog
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Immunogen
Synthetic peptide corresponding to Human H2R aa 335-349 (C terminal).
Sequence:QEEKPLKLQVWSGTE
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Positive control
- WB: Human tonsil tissue lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline -
Concentration information loading... -
Purity
Immunogen affinity purified -
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab39964 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.
A 1 hour primary incubation is recommended for this product. |
| Notes |
|---|
|
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa. A 1 hour primary incubation is recommended for this product. |
Target
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Function
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 3274 Human
- Entrez Gene: 15466 Mouse
- Omim: 142703 Human
- SwissProt: P25021 Human
- SwissProt: P97292 Mouse
- Unigene: 247885 Human
- Unigene: 57243 Mouse
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Alternative names
- Gastric receptor 1 antibody
- Gastric receptor I antibody
- H2R antibody
see all
Images
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Western blot - Anti-H2R antibody (ab39964)Anti-H2R antibody (ab39964) at 1 µg/ml + Human tonsil tissue lysates (35µg protein in RIPA buffer)
Predicted band size: 40 kDaDetected by chemiluminescence.
Protocols
Datasheets and documents
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Datasheet download
References (0)
ab39964 has not yet been referenced specifically in any publications.
