Recombinant
RabMAb

Anti-H6PD / GDH antibody [EPR12338(B)] (ab170895)

Overview

  • Product name
    Anti-H6PD / GDH antibody [EPR12338(B)]
    See all H6PD / GDH primary antibodies
  • Description
    Rabbit monoclonal [EPR12338(B)] to H6PD / GDH
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    within Human H6PD/ GDH aa 750 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
    Database link: O95479

  • Positive control
    • Fetal liver, MCF-7, rat liver, HepG2 and mouse liver lysates; Human kidney and stomach tissue.
  • General notes

     

     

    Previously labelled as H6PD.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab170895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 89 kDa.
IHC-P 1/50 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IP.
  • Target

    • Function
      Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
    • Tissue specificity
      Present in most tissues examined, strongest in liver.
    • Involvement in disease
      Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
    • Sequence similarities
      In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.
      In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
    • Cellular localization
      Endoplasmic reticulum lumen. Microsomes, endoplasmic reticulum lumen.
    • Information by UniProt
    • Database links
    • Alternative names
      • 6 phosphogluconolactonase antibody
      • 6-phosphogluconolactonase antibody
      • 6PGL antibody
      • CORTRD1 antibody
      • G6PD, H form antibody
      • G6PDH antibody
      • G6PE_HUMAN antibody
      • GDH antibody
      • GDH/6PGL endoplasmic bifunctional protein antibody
      • Glucose 1 dehydrogenase antibody
      • Glucose 6 phosphate dehydrogenase, salivary antibody
      • Glucose dehydrogenase antibody
      • Glucose dehyrogenase antibody
      • Gpd1 antibody
      • H6pd antibody
      • Hexose 6 phosphate dehydrogenase (glucose 1 dehydrogenase) antibody
      • Hexose 6 phosphate dehydrogenase antibody
      • Hexose-6-phosphate dehydrogenase antibody
      see all

    Images

    • Immunohistochemical analysis of paraffin-embedded Human stomach tissue labeling H6PD with ab170895 at 1/50 dilution.

    • Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling H6PD with ab170895 at 1/50 dilution.

    • All lanes : Anti-H6PD / GDH antibody [EPR12338(B)] (ab170895) at 1/1000 dilution

      Lane 1 : Fetal liver lysate
      Lane 2 : MCF-7 lysate
      Lane 3 : Rat liver lysate
      Lane 4 : HepG2 lysate
      Lane 5 : Mouse liver lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 89 kDa

    References

    ab170895 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab170895.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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