Overview

  • Product name

  • Description

    Rabbit polyclonal to H6PD/GDH
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human H6PD/GDH (internal sequence). The exact sequence is proprietary.
    Database link: O95479

  • Positive control

    • WB: Mouse liver tissue lysate; HepG2 whole cell lysate. IHC-P: Human colon carcinoma tissue.
  • General notes

    Previously labelled as H6PD.

Properties

Applications

Our Abpromise guarantee covers the use of ab228423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 89 kDa.

Target

  • Function

    Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
  • Tissue specificity

    Present in most tissues examined, strongest in liver.
  • Involvement in disease

    Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • Sequence similarities

    In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.
    In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
  • Cellular localization

    Endoplasmic reticulum lumen. Microsomes, endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links

  • Alternative names

    • 6 phosphogluconolactonase antibody
    • 6-phosphogluconolactonase antibody
    • 6PGL antibody
    • CORTRD1 antibody
    • G6PD, H form antibody
    • G6PDH antibody
    • G6PE_HUMAN antibody
    • GDH antibody
    • GDH/6PGL endoplasmic bifunctional protein antibody
    • Glucose 1 dehydrogenase antibody
    • Glucose 6 phosphate dehydrogenase, salivary antibody
    • Glucose dehydrogenase antibody
    • Glucose dehyrogenase antibody
    • Gpd1 antibody
    • H6pd antibody
    • Hexose 6 phosphate dehydrogenase (glucose 1 dehydrogenase) antibody
    • Hexose 6 phosphate dehydrogenase antibody
    • Hexose-6-phosphate dehydrogenase antibody
    see all

Images

  • Paraffin-embedded human colon carcinoma tissue stained for H6PD/GDH with ab228423 at 1/500 dilution in immunohistochemical analysis.

  • Anti-H6PD/GDH antibody (ab228423) at 1/1000 dilution + HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 89 kDa



    7.5% SDS-PAGE

  • Anti-H6PD/GDH antibody (ab228423) at 1/1000 dilution + Mouse liver tissue lysate at 50 µg

    Developed using the ECL technique.

    Predicted band size: 89 kDa



    7.5% SDS-PAGE

References

ab228423 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228423.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up