Overview

  • Product name

    H7, Protein kinase inhibitor
  • Description

    Protein kinase inhibitor
  • Biological description

    Protein kinase inhibitor. Inhibits the activity of PKA, PKG, PKC and MLCK (Ki values are 3.0 (PKA), 5.8 (PKG), 6.0 (PKC) and 97 µM (MLCK) respectively).
  • Purity

    > 98%
  • CAS Number

    108930-17-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Steketee JD Intra-ventral tegmental area administration of H7 delays, but does not prevent the development of cocaine-induced sensitization. Brain Res Bull 43:565-71 (1997). Read more (PubMed: 9254028) »
  • Quick J  et al. The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem Biophys Res Commun 187:657-63 (1992). Read more (PubMed: 1530623) »
  • Ratz PH Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries. J Pharmacol Exp Ther 252:253-9 (1990). Read more (PubMed: 2299593) »
  • Hidaka H  et al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036-41 (1984). Read more (PubMed: 6238627) »

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