H8 dihydrochloride, cGMP and cAMP-dependent kinases inhibitor (ab142309)

Overview

  • Product name

    H8 dihydrochloride, cGMP and cAMP-dependent kinases inhibitor
  • Description

    cGMP- and cAMP-dependent kinases inhibitor
  • Biological description

    cGMP- and cAMP-dependent kinases inhibitor. Inhibits the activity of PKG (Ki = 0.48 µM) and PKA (Ki = 1.2 µM). Also inhibits PKC (Ki = 15 µM) and myosin-light chain kinase (MLCK; Ki = 68 µM) activity.
  • Purity

    > 98%
  • CAS Number

    113276-94-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Rosado E  et al. Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. Biochim Biophys Acta 1590:1-15 (2002). Read more (PubMed: 12063164) »
  • Jung CS  et al. Run-up of gamma-aminobutyric acid(C) responses in catfish retinal cone-horizontal cell axon-terminals is modulated by protein kinase A and C. Neurosci Lett 282:53-6 (2000). Read more (PubMed: 10713394) »
  • Bilsky EJ  et al. Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. J Pharmacol Exp Ther 277:484-90 (1996). Read more (PubMed: 8613958) »
  • Hidaka H  et al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036-41 (1984). Read more (PubMed: 6238627) »

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