HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor (ab145524)

Overview

  • Product name

    HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor
  • Description

    Selective, ATP-competitive, reversible Rho-kinase inhibitor
  • Alternative names

    • Hydroxyfasudil
  • Biological description

    Selective, ATP-competitive, reversible Rho-kinase inhibitor (IC50 values are 0.6 and 0.8 μM for Rock-1 and Rock-2, respectively). Cell-permeable active Fasudil (ab120306) metabolite. Inhibits neutrophil migration and shows potent vasodilatory effects in vivo.
  • Purity

    > 99%
  • CAS Number

    155558-32-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone hydrochloride
  • Molecular weight

    343.83
  • Molecular formula

    C14H17N3O3S.HCl
  • PubChem identifier

    11371328
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Taniguchi J  et al. Evaluation of Rho-kinase activity in mice brain using N-[11C]methyl-hydroxyfasudil with positron emission tomography. Mol Imaging Biol 16:395-402 (2014). Read more (PubMed: 24155033) »
  • Fujii M  et al. Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats. Neurochem Int 60:327-33 (2012). Read more (PubMed: 22226843) »
  • Nakamura K  et al. Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase. J Cereb Blood Flow Metab 21:876-85 (2001). Read more (PubMed: 11435800) »

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