Hainantoxin-III, TTX-sensitive voltage-gated Na+ channel blocker (ab146037)

Overview

  • Product name

    Hainantoxin-III, TTX-sensitive voltage-gated Na+ channel blocker
  • Description

    Potent, selective TTX-sensitive voltage-gated Na+ channel blocker
  • Biological description

    Potent, selective TTX-sensitive voltage-gated Na+ channel blocker (IC50 = 1.1 nM). Hainantoxin-IV (ab146038) analog. Shows neurotoxic effects in vivo.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Liu Z  et al. Sequence-specific 1H-NMR assignment and determination of the secondary structure of hainantoxin-III from the spider Ornithoctonus hainana. Protein Pept Lett 20:761-6 (2013). Read more (PubMed: 22973848) »
  • Liu Z  et al. Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana. J Biol Chem 288:20392-403 (2013). Read more (PubMed: 23703613) »
  • Xiao Y & Liang S Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol 477:1-7 (2003). Read more (PubMed: 14512091) »

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