Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR20341-34] to Haptoglobin
- Suitable for: Sandwich ELISA
- Reacts with: Human
Product nameAnti-Haptoglobin antibody [EPR20341-34]
See all Haptoglobin primary antibodies
DescriptionRabbit monoclonal [EPR20341-34] to Haptoglobin
Tested applicationsSuitable for: Sandwich ELISAmore details
Species reactivityReacts with: Human
The details of the immunogen for this antibody are not available.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab222627 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Sandwich ELISA||Use at an assay dependent concentration.|
FunctionAs a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Tissue specificityExpressed by the liver and secreted in plasma.
Involvement in diseaseAnhaptoglobinemia
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 2 Sushi (CCP/SCR) domains.
- Information by UniProt
- Binding peptide antibody
- BP antibody
- Haptoglobin alpha chain antibody
Example of human Haptoglobin standard curve in 1X Cell Extraction Buffer PTR using recombinant Haptoglobin RabMAb antibody (ab222627) and a recombinant monoclonal antibody. Background-subtracted values (mean +/- SD) are graphed.
For a complete ELISA kit, see Human Haptoglobin ELISA kit (ab219048).
For a matched antibody pair set, see Human Haptoglobin Matched Antibody Pair Kit (ab219542).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab222627 has not yet been referenced specifically in any publications.