Recombinant
RabMAb

Recombinant Anti-Haptoglobin antibody [EPSISR7] - BSA and Azide free (ab226117)

Overview

  • Product name

    Anti-Haptoglobin antibody [EPSISR7] - BSA and Azide free
    See all Haptoglobin primary antibodies
  • Description

    Rabbit monoclonal [EPSISR7] to Haptoglobin - BSA and Azide free
  • Host species

    Rabbit
  • Specificity

    This antibody may also recognize Haptoglobin or Haptoglobin-related protein based on the immunogen sequences.

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Haptoglobin aa 350-450 (C terminal). The exact sequence is proprietary.

  • Positive control

    • Human plasma and fetal liver lysates
  • General notes

    Ab226117 is the carrier-free version of ab131236. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    ab226117 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Monoclonal
  • Clone number

    EPSISR7
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab226117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 45 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
      Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
    • Tissue specificity

      Expressed by the liver and secreted in plasma.
    • Involvement in disease

      Anhaptoglobinemia
    • Sequence similarities

      Belongs to the peptidase S1 family.
      Contains 1 peptidase S1 domain.
      Contains 2 Sushi (CCP/SCR) domains.
    • Cellular localization

      Secreted.
    • Information by UniProt
    • Database links

    • Alternative names

      • Binding peptide antibody
      • BP antibody
      • Haptoglobin alpha chain antibody
      • Haptoglobin alpha(1S) beta antibody
      • Haptoglobin alpha(2FS) beta antibody
      • Haptoglobin beta chain antibody
      • Haptoglobin, alpha polypeptide antibody
      • Haptoglobin, beta polypeptide antibody
      • HP antibody
      • HP2 ALPHA2 antibody
      • HP2ALPHA2 antibody
      • HPA1S antibody
      • HPT antibody
      • HPT_HUMAN antibody
      • MGC111141 antibody
      • Zonulin antibody
      see all

    References

    ab226117 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab226117.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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