Overview

  • Product name

    Harmine, DYRK1A inhibitor
  • Description

    Potent and selective inhibitor of DYRK1A
  • Biological description

    Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
  • Purity

    > 98%
  • CAS Number

    442-51-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
  • Molecular weight

    212.25
  • Molecular formula

    C13H12N2O
  • PubChem identifier

    5280953
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COc1ccc3c(c1)nc2c3ccnc2C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Waki H  et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5:357-70 (2007). Read more (PubMed: 17488638) »
  • Bain J  et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007). Read more (PubMed: 17850214) »
  • Song Y  et al. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem Biophys Res Commun 317:128-32 (2004). Read more (PubMed: 15047157) »
See 1 Publication for this product

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