Harringtonine, translational protein synthesis inhibitor (ab141941)

Overview

  • Product name

    Harringtonine, translational protein synthesis inhibitor
  • Description

    Translational protein synthesis inhibitor
  • Biological description

    Natural cephalotaxus alkaloid. Blocks protein synthesis through translation elongation inhibition. Immobilizes ribosomes following translation initiation to reveal footprints of initiation sites in vitro. Antitumor agent. Active in vivo.
  • Purity

    > 95%
  • CAS Number

    26833-85-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine
  • Molecular weight

    531.60
  • Molecular formula

    C28H37NO9
  • PubChem identifier

    29927670
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
  • Source

    Cephalotaxus harringtonia

  • Research areas

References

This product has been referenced in:

  • Ingolia NT  et al. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc 7:1534-50 (2012). Read more (PubMed: 22836135) »
  • Robert F  et al. Altering chemosensitivity by modulating translation elongation. PLoS One 4:e5428 (2009). Read more (PubMed: 19412536) »
  • Fresno M  et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem 72:323-30 (1977). Read more (PubMed: 319998) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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