Anti-HB9/HLXB9/MNX1 antibody (ab92606)
Key features and details
- Rabbit polyclonal to HB9/HLXB9/MNX1
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-HB9/HLXB9/MNX1 antibody
See all HB9/HLXB9/MNX1 primary antibodies -
Description
Rabbit polyclonal to HB9/HLXB9/MNX1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Dog -
Immunogen
Synthetic peptide corresponding to Mouse HB9/HLXB9/MNX1 aa 330-380.
Database link: NP_064328.2 -
Positive control
- WB: MOLT 4 cell lysate; IHC-P: Mouse pancreas tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab92606 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 41 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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WB
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 41 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Putative transcription factor involved in pancreas development and function. -
Tissue specificity
Expressed in lymphoid and pancreatic tissues. -
Involvement in disease
Defects in MNX1 are a cause of Currarino syndrome (CURRAS) [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. -
Sequence similarities
Contains 1 homeobox DNA-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 3110 Human
- Entrez Gene: 15285 Mouse
- Omim: 142994 Human
- SwissProt: P50219 Human
- SwissProt: Q9QZW9 Mouse
- Unigene: 37035 Human
- Unigene: 103760 Mouse
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Alternative names
- HB 9 antibody
- HB9 antibody
- HLXB 9 antibody
see all
Images
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Immunohistochemistry analysis of HB9/HLXB9/MNX1 expression in formalin-fixed, paraffin-embedded Mouse pancreas tissue using: an isotype control (1) or ab92606 at 5µg/ml (2 and 3).
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All lanes : Anti-HB9/HLXB9/MNX1 antibody (ab92606) at 0.5 µg/ml
Lane 1 : MOLT 4 cell lysate
Lane 2 : MOLT 4 cell lysate with immunizing peptide
Secondary
All lanes : HRP-conjugated Goat anti-Rabbit IgG
Predicted band size: 41 kDa
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab92606 has been referenced in 6 publications.
- Miralles MP et al. Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons. Front Cell Neurosci 16:1054270 (2022). PubMed: 36619669
- Sansa A et al. Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons. Neurobiol Dis 155:105366 (2021). PubMed: 33845129
- Sansa A et al. Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons. Acta Neuropathol Commun 9:122 (2021). PubMed: 34217376
- de la Fuente S et al. Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models. Cell Death Dis 11:487 (2020). PubMed: 32587237
- Cosset É et al. Modeling Poliovirus Infection Using Human Engineered Neural Tissue Enriched With Motor Neuron Derived From Embryonic Stem Cells. Front Cell Dev Biol 8:593106 (2020). PubMed: 33490061
- Osaki T et al. On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Nat Protoc 15:421-449 (2020). PubMed: 31932771