The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 44 kDa (predicted molecular weight: 41 kDa).
Putative transcription factor involved in pancreas development and function.
Expressed in lymphoid and pancreatic tissues.
Involvement in disease
Defects in MNX1 are a cause of Currarino syndrome (CURRAS) [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.
The predicted molecular weight of HB9/HLXB9 is 41 kDa (SwissProt), however we expect to observe a banding pattern at 44 kDa. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.