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Anti-HB9/HLXB9/MNX1 antibody (ab221884)

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Immunocytochemistry/ Immunofluorescence - Anti-HB9/HLXB9/MNX1 antibody (ab221884)

    Key features and details

    • Rabbit polyclonal to HB9/HLXB9/MNX1
    • Suitable for: ICC/IF
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-HB9/HLXB9/MNX1 antibody
      See all HB9/HLXB9/MNX1 primary antibodies
    • Description

      Rabbit polyclonal to HB9/HLXB9/MNX1
    • Host species

      Rabbit
    • Tested applications

      Suitable for: ICC/IFmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Recombinant fragment corresponding to Human HB9/HLXB9/MNX1 aa 6-43.
      Sequence:

      NFRIDALLAVDPPRAASAQSAPLALVTSLAAAASGTGG


      Database link: P50219
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • ICC/IF: MCF7 cells.
    • General notes

       This product was previously labelled as HB9/HLXB9

       

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.20
      Preservative: 0.02% Sodium azide
      Constituents: 40% Glycerol (glycerin, glycerine), PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Soma marker
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Developmental Families
      • Other
      • Stem Cells
      • Lineage Markers
      • Ectoderm
      • Stem Cells
      • Neural Stem Cells
      • Neuron Restricted Lineage
      • Developmental Biology
      • Lineage specification
      • Ectoderm

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    Our Abpromise guarantee covers the use of ab221884 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    ICC/IF Use a concentration of 0.25 - 2 µg/ml.

    Fixation/Permeabilization: PFA/Triton X-100.

    Target

    • Function

      Putative transcription factor involved in pancreas development and function.
    • Tissue specificity

      Expressed in lymphoid and pancreatic tissues.
    • Involvement in disease

      Defects in MNX1 are a cause of Currarino syndrome (CURRAS) [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.
    • Sequence similarities

      Contains 1 homeobox DNA-binding domain.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P50219 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 3110 Human
      • Omim: 142994 Human
      • SwissProt: P50219 Human
      • Unigene: 37035 Human
      • Alternative names

        • HB 9 antibody
        • HB9 antibody
        • HLXB 9 antibody
        • HLXB9 antibody
        • Homeo box HB9 antibody
        • Homeobox HB9 antibody
        • Homeobox protein HB9 antibody
        • HOXHB9 antibody
        • MNX1 antibody
        • MNX1_HUMAN antibody
        • Motor neuron and pancreas homeobox 1 antibody
        • Motor neuron and pancreas homeobox protein 1 antibody
        • Sacral agenesis autosomal dominant (Currarino triad) antibody
        • SCRA 1 antibody
        • SCRA1 antibody
        see all

      Images

      • Immunocytochemistry/ Immunofluorescence - Anti-HB9/HLXB9/MNX1 antibody (ab221884)
        Immunocytochemistry/ Immunofluorescence - Anti-HB9/HLXB9/MNX1 antibody (ab221884)

        PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for HB9/HLXB9/MNX1 (green) using ab221884 at 4 µg/ml in ICC/IF.

      Protocols

      • Immunocytochemistry & immunofluorescence protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
      • SDS
    • References (0)

      Publishing research using ab221884? Please let us know so that we can cite the reference in this datasheet.

      ab221884 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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