Overview

  • Product name
    HBDDE, PKCalpha and PKCgamma inhibitor
  • Description
    Selective PKCα and PKCγ inhibitor
  • Biological description
    PKCα and PKCγ inhibitor (IC50 values are 43 and 50 μM respectively). δ, βI and βII isotypes are not affected. Inducer of apoptosis. Active in vivo.
  • Purity
    > 97%

Properties

  • Chemical name
    5-(Methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol
  • Molecular weight
    338.30
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C16H18O8
  • CAS Number
    154675-18-0
  • PubChem identifier
    3568
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 50 mM and in ethanol to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COCC1=CC(=C(C(=C1C2=C(C(=C(C=C2COC)O)O)O)O)O)O
  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:
  • Dhein S  et al. Protein kinase Calpha mediates the effect of antiarrhythmic peptide on gap junction conductance. Cell Commun Adhes 8:257-64 (2001). Read more (PubMed: 12064599) »
  • Inoue M & Ueda H Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice. J Pharmacol Exp Ther 293:662-9 (2000). Read more (PubMed: 10773042) »
  • Mathur A & Vallano ML 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol 60:809-15 (2000). Read more (PubMed: 10930535) »
  • Kashiwada Y  et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem 37:195-200 (1994). Read more (PubMed: 8289196) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141573.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up