HC-030031, TRPA1 blocker (ab120554)
- Datasheet
- References (1)
Overview
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Product name
HC-030031, TRPA1 blocker -
Description
TRPA1 blocker, orally active -
Biological description
Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling. -
Purity
> 99% -
CAS Number
349085-38-7 -
Chemical structure
Properties
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Chemical name
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide -
Molecular weight
355.40 -
Molecular formula
C18H21N5O3 -
PubChem identifier
1150897 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)c1ccc(cc1)NC(=O)Cn3cnc2c3C(=O)N(C)C(=O)N2C -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Ro JY et al. Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia. Pain 144:270-7 (2009). Read more (PubMed: 19464796) »
- Eid SR et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 4:48 (2008). Read more (PubMed: 18954467) »
- McNamara CR et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A 104:13525-30 (2007). Read more (PubMed: 17686976) »
