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  1. Link

    hc-030031-trpa1-blocker-ab120554.pdf

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HC-030031, TRPA1 blocker (ab120554)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (5)

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Chemical Structure - HC-030031, TRPA1 blocker (ab120554)

    Key features and details

    • TRPA1 blocker, orally active
    • CAS Number: 349085-38-7
    • Soluble in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      HC-030031, TRPA1 blocker
    • Description

      TRPA1 blocker, orally active
    • Biological description

      Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling.

    • CAS Number

      349085-38-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
    • Molecular weight

      355.40
    • Molecular formula

      C18H21N5O3
    • PubChem identifier

      1150897
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(C)c1ccc(cc1)NC(=O)Cn3cnc2c3C(=O)N(C)C(=O)N2C
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • More Ion Channels
      • Neuroscience
      • Sensory System
      • Somatosensory system
      • Nociception
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Ion Channels
      • TRP
      • Blockers
      • Biochemicals
      • Research Area
      • Diabetes
      • TRP
      • Blockers
      • Biochemicals
      • Research Area
      • Heart disease
      • TRP
      • Blockers
      • Biochemicals
      • Research Area
      • Hypertension
      • TRP
      • Blockers
      • Biochemicals
      • Research Area
      • Obesity
      • TRP
      • Blockers
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      • Research Area
      • Pain & inflammation
      • TRP
      • Blockers
      • Biochemicals
      • Research Area
      • Respiratory disease
      • TRP
      • Blockers
      • Biochemicals
      • Research Area
      • Stroke
      • TRP
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      • Neuroscience
      • Processes

    Images

    • Chemical Structure - HC-030031, TRPA1 blocker (ab120554)
      Chemical Structure - HC-030031, TRPA1 blocker (ab120554)
      2D chemical structure image of ab120554, HC-030031, TRPA1 blocker

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (5)

    Publishing research using ab120554? Please let us know so that we can cite the reference in this datasheet.

    ab120554 has been referenced in 5 publications.

    • Anil SM  et al. Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages. Sci Rep 11:1462 (2021). PubMed: 33446817
    • Anis O  et al. Cannabis-Derived Compounds Cannabichromene and ?9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization. Molecules 26:N/A (2021). PubMed: 33477303
    • Peeri H  et al. Specific Compositions of Cannabis sativa Compounds Have Cytotoxic Activity and Inhibit Motility and Colony Formation of Human Glioblastoma Cells In Vitro. Cancers (Basel) 13:N/A (2021). PubMed: 33916466
    • Masuoka T  et al. TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root Ganglion Neurons. Front Physiol 8:272 (2017). PubMed: 28515697
    • White BJ  et al. Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats. Br J Pharmacol 168:785-93 (2013). PubMed: 22928888

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Dear professor:
    HAVE A NICE DAY!

    I have purchased your product hc-030031, I would like to ask your hc-030031 the amount of intrathecal administration in rats?
    Could you provide a few articles about the intrathecal injection of hc-030031 literature?

    Thank you very much for taking the time to read this message.

    Very much looking forward to your answers.

    GOOD LUCK!

    Read More

    Abcam community

    Verified customer

    Asked on Apr 25 2012

    Answer

    Thank you for your enquiry.

    I am sorry we have no information from our own testing or from customers regarding the use of ab120554 HC-030031for intrathecal administration in rats.

    I have done a general literature search for hc-030031 intrathecal administration in rats. The following publication indicates they have used 100 and300 mg/kg, suspended in 0.5% Methylcellulose and the drug was dosed p.o. at a volume of 10 ml/kg.

    HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
    Samer R Eid
    Molecular Pain 2008, 4:48
    http://www.molecularpain.com/content/4/1/48

    For more information, I can recommend to try a more extensive literature search:
    https://www.google.com/search?q=intrathecal+administration+HC-030031&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-GB:official&client=firefox-a

    I hope this will be helpful to you. If you require any further information, please do not hesitate to contact us.

    Read More

    Abcam Scientific Support

    Answered on Apr 25 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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