Key features and details
- Rabbit polyclonal to HC-II
- Suitable for: ICC/IF, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-HC-II antibody
See all HC-II primary antibodies
DescriptionRabbit polyclonal to HC-II
Tested applicationsSuitable for: ICC/IF, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide corresponding to Human HC-II (internal sequence).
Database link: P05546
- Human liver carcinoma tissue; HepG2 cells.
Protein previously labeled as Heparin Cofactor II.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS, 0.87% Sodium chloride
PBS without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab196758 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Our Abpromise guarantee covers the use of ab196758 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/100 - 1/500.|
|IHC-P||1/50 - 1/100.|
FunctionThrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Tissue specificityExpressed predominantly in liver. Also present in plasma.
Involvement in diseaseThrombophilia due to heparin cofactor 2 deficiency
Sequence similaritiesBelongs to the serpin family.
DomainThe N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
modificationsPhosphorylation sites are present in the extracellular medium.
- Information by UniProt
- D22S673 antibody
- HC II antibody
- HC-II antibody
ab196758 has not yet been referenced specifically in any publications.