Key features and details
- Rabbit polyclonal to hCG
- Reacts with: Human
- Isotype: IgG
Product nameAnti-hCG antibody
See all hCG primary antibodies
DescriptionRabbit polyclonal to hCG
SpecificityThis antibody recognises both alpha and beta subunits of hCG.
Species reactivityReacts with: Human
Purified Chorionic Gonadotropin from human placental glucoprotein urine.
- Purified human CG and rat liver tissue lysate.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 0.5% BSA, 30% Glycerol, PBS
Concentration information loading...
PurityProtein A purified
RelevanceHuman chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma.
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ab54410 has been referenced in 7 publications.
- Zhu H et al. NPFF increases fusogenic proteins syncytin 1 and syncytin 2 via GCM1 in first trimester primary human cytotrophoblast cells. FASEB J N/A:N/A (2020). PubMed: 32501590
- Lu X et al. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta 39:45-54 (2016). PubMed: 26992674
- Li Y et al. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction 149:339-46 (2015). PubMed: 25614620
- Zhou Z et al. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta 35:907-18 (2014). PubMed: 25175744
- Wang R et al. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod 90:117 (2014). PubMed: 24740598
- Zhou Z et al. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis 4:e593 (2013). WB ; Human . PubMed: 23598405
- Dukic-Stefanovic S et al. Chorionic gonadotropin and its receptor are both expressed in human retina, possible implications in normal and pathological conditions. PLoS One 7:e52567 (2012). WB ; Human . PubMed: 23285091