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    hcg-antibody-ab54410.pdf

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Signal Transduction Growth Factors/Hormones Hormones
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Anti-hCG antibody (ab54410)

  • Datasheet
  • SDS
Submit a review Q&A (1)References (7)

Product price, shipping and contact information

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Abpromise

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Key features and details

  • Rabbit polyclonal to hCG
  • Reacts with: Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-hCG antibody
    See all hCG primary antibodies
  • Description

    Rabbit polyclonal to hCG
  • Host species

    Rabbit
  • Specificity

    This antibody recognises both alpha and beta subunits of hCG.
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Purified Chorionic Gonadotropin from human placental glucoprotein urine.

  • Positive control

    • Purified human CG and rat liver tissue lysate.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.5% BSA, 30% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Growth Factors/Hormones
    • Hormones
    • Cancer
    • Growth factors
    • Hormones
    • Cancer
    • Tumor biomarkers
    • Hormones
    • Developmental Biology
    • Reproduction
    • Hormones
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Hormone biosynthesis
    • Metabolism
    • Pathways and Processes
    • Endocrine metabolism
    • Hormone biosynthesis
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Target

  • Relevance

    Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma.
  • Cellular localization

    Secreted
  • Database links

    • Entrez Gene: 1081 Human
    • Entrez Gene: 1082 Human
    • Omim: 118850 Human
    • Omim: 118860 Human
    • SwissProt: P01215 Human
    • SwissProt: P01233 Human
    • Unigene: 119689 Human
    • Unigene: 446683 Human
    • Unigene: 743279 Human
    see all
  • Alternative names

    • anterior pituitary glycoprotein hormones common subunit alpha antibody
    • CG alpha antibody
    • CG-ALPHA antibody
    • CGB antibody
    • CGB3 antibody
    • CGB5 antibody
    • CGB7 antibody
    • choriogonadotropin alpha chain antibody
    • Chorionic gonadotrophin chain beta antibody
    • chorionic gonadotrophin subunit alpha antibody
    • chorionic gonadotropin beta 3 subunit antibody
    • Chorionic gonadotropin beta chain antibody
    • Chorionic gonadotropin beta subunit antibody
    • chorionic gonadotropin, alpha polypeptide antibody
    • chorionic gonadotropin, beta polypeptide 3 antibody
    • chorionic gonadotropin, beta polypeptide antibody
    • Follicle stimulating hormone alpha chain antibody
    • follicle-stimulating hormone alpha chain antibody
    • follicle-stimulating hormone alpha subunit antibody
    • follitropin alpha chain antibody
    • FSH Alpha antibody
    • FSH-alpha antibody
    • FSHA antibody
    • glycoprotein hormones alpha chain antibody
    • glycoprotein hormones, alpha polypeptide antibody
    • GPHa antibody
    • GPHA1 antibody
    • HCG antibody
    • hCGB antibody
    • Human Chorionic Gonadotropin antibody
    • LHA antibody
    • LSH alpha antibody
    • LSH-alpha antibody
    • luteinizing hormone alpha chain antibody
    • lutropin alpha chain antibody
    • Thyroid stimulating hormone alpha chain antibody
    • thyroid-stimulating hormone alpha chain antibody
    • thyrotropin alpha chain antibody
    • TSH Alpha antibody
    • TSH-alpha antibody
    • TSHA antibody
    see all

Protocols

  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (7)

    Publishing research using ab54410? Please let us know so that we can cite the reference in this datasheet.

    ab54410 has been referenced in 7 publications.

    • Zhu H  et al. NPFF increases fusogenic proteins syncytin 1 and syncytin 2 via GCM1 in first trimester primary human cytotrophoblast cells. FASEB J N/A:N/A (2020). PubMed: 32501590
    • Lu X  et al. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta 39:45-54 (2016). PubMed: 26992674
    • Li Y  et al. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction 149:339-46 (2015). PubMed: 25614620
    • Zhou Z  et al. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta 35:907-18 (2014). PubMed: 25175744
    • Wang R  et al. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod 90:117 (2014). PubMed: 24740598
    • Zhou Z  et al. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis 4:e593 (2013). WB ; Human . PubMed: 23598405
    • Dukic-Stefanovic S  et al. Chorionic gonadotropin and its receptor are both expressed in human retina, possible implications in normal and pathological conditions. PLoS One 7:e52567 (2012). WB ; Human . PubMed: 23285091

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Dear technical team,   Our customer purchased this antibody and would like to know the PI point of ab54410. If you have information, please let me know. Thank you.   Best regards,

    Read More

    Abcam community

    Verified customer

    Asked on Sep 28 2011

    Answer

    Thank you for your enquiry and your interest in our products. The PI value has not been characterized in this case. If you need anything further or any help then please let me know.

    Read More

    Abcam Scientific Support

    Answered on Sep 28 2011

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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