Overview

  • Product name

    Anti-hCG receptor/LHR antibody [8G9A2]
    See all hCG receptor/LHR primary antibodies
  • Description

    Mouse monoclonal [8G9A2] to hCG receptor/LHR
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cyt, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Tissue, cells or virus corresponding to Mouse hCG receptor/LHR. LHR-29 cells.
    Database link: P22888

  • Positive control

    • HepG2, Jurkat and SMMC-7721 cell lysates; Jurkat cells.
  • General notes

    This product was changed from ascites to supernatant. Lot no’s high than GR273983-8 are from Tissue Culture Supernatant

     This product was previously labelled as hCG receptor

     

Properties

Applications

Our Abpromise guarantee covers the use of ab204950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/200 - 1/400.
WB 1/500 - 1/2000. Predicted molecular weight: 78 kDa.
ICC/IF 1/200 - 1/1000.

Target

  • Function

    Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • Tissue specificity

    Gonadal and thyroid cells.
  • Involvement in disease

    Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.
    Defects in LHCGR are the cause of luteinizing hormone resistance (LHR) [MIM:238320]; also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    Contains 6 LRR (leucine-rich) repeats.
    Contains 1 LRRNT domain.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gonadotropin receptor antibody
    • Gpcr19-rs1 antibody
    • GTHR-II antibody
    • HHG antibody
    • LCGR antibody
    • LGR2 antibody
    • LH-R antibody
    • LH/CG R antibody
    • LH/CG-R antibody
    • LH/CGR antibody
    • LHCGR antibody
    • LHR antibody
    • LHRHR antibody
    • LSH R antibody
    • LSH-R antibody
    • LSHR_HUMAN antibody
    • Luteinizing hormone receptor antibody
    • Luteinizing hormone/choriogonadotropin receptor antibody
    • Lutropin choriogonadotropic hormone receptor antibody
    • Lutropin choriogonadotropic receptor antibody
    • Lutropin-choriogonadotropic hormone receptor antibody
    • ULG5 antibody
    see all

Images

  • All lanes : Anti-hCG receptor/LHR antibody [8G9A2] (ab204950) at 1/500 dilution

    Lane 1 : HepG2 cell lysate
    Lane 2 : Jurkat cell lysate
    Lane 3 : SMMC-7721 cell lysate

    Predicted band size: 78 kDa

  • Flow cytometric analysis of Jurkat cells labeling hCG receptor/LHR with ab204950 at 1/200 dilution (green) compared with a negative control (red).

References

This product has been referenced in:

  • Quinn MA  et al. Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice. Cell Rep 22:2690-2701 (2018). WB ; Mouse . Read more (PubMed: 29514097) »
  • Zhao R  et al. Human chorionic gonadotropin promotes cell proliferation through the activation of c-Met in gastric cancer cells. Oncol Lett 16:4271-4278 (2018). Read more (PubMed: 30197669) »
See all 2 Publications for this product

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