Anti-HCN2 antibody (ab19346)
Key features and details
- Rabbit polyclonal to HCN2
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-HCN2 antibody
See all HCN2 primary antibodies -
Description
Rabbit polyclonal to HCN2 -
Host species
Rabbit -
Tested Applications & Species
Application Species WB Human -
Immunogen
Synthetic peptide corresponding to Human HCN2 aa 874-889.
Sequence:G-LDPQDSARSRLSSNL
Database link: Q9UL51 -
Positive control
- rat brain lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab19346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Application | Species |
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WB |
Human
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All applications |
Mouse
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Application | Abreviews | Notes |
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WB |
1/100. Detects a band of approximately 100,115 kDa.
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Notes |
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WB
1/100. Detects a band of approximately 100,115 kDa. |
Target
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Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. -
Tissue specificity
Highly expressed throughout the brain. Detected at low levels in heart. -
Sequence similarities
Belongs to the potassium channel HCN family.
Contains 1 cyclic nucleotide-binding domain. -
Domain
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 610 Human
- Entrez Gene: 15166 Mouse
- Entrez Gene: 114244 Rat
- Omim: 602781 Human
- SwissProt: Q9UL51 Human
- SwissProt: O88703 Mouse
- SwissProt: Q9JKA9 Rat
- Unigene: 124161 Human
see all -
Alternative names
- BCNG-2 antibody
- BCNG2 antibody
- Brain cyclic nucleotide gated channel 2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab19346 has been referenced in 5 publications.
- Zhang W et al. Implantation of engineered conduction tissue in the rat heart. Mol Med Rep 19:2687-2697 (2019). PubMed: 30720107
- Yang L et al. HCN channel antagonist ZD7288 ameliorates neuropathic pain and associated depression. Brain Res 1717:204-213 (2019). PubMed: 30940440
- Kretschmannova K et al. The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells. Mol Endocrinol 26:153-64 (2012). WB ; Rat . PubMed: 22135067
- Adams BE et al. Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1. Exp Neurol 219:249-57 (2009). WB . PubMed: 19500574
- Fyk-Kolodziej B & Pourcho RG Differential distribution of hyperpolarization-activated and cyclic nucleotide-gated channels in cone bipolar cells of the rat retina. J Comp Neurol 501:891-903 (2007). PubMed: 17311321