Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab19346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/100. Detects a band of approximately 100,115 kDa.|
FunctionHyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
Tissue specificityHighly expressed throughout the brain. Detected at low levels in heart.
Sequence similaritiesBelongs to the potassium channel HCN family.
Contains 1 cyclic nucleotide-binding domain.
DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
- Information by UniProt
- BCNG-2 antibody
- BCNG2 antibody
- Brain cyclic nucleotide gated channel 2 antibody
This product has been referenced in:
- Zhang W et al. Implantation of engineered conduction tissue in the rat heart. Mol Med Rep 19:2687-2697 (2019). Read more (PubMed: 30720107) »
- Yang L et al. HCN channel antagonist ZD7288 ameliorates neuropathic pain and associated depression. Brain Res 1717:204-213 (2019). Read more (PubMed: 30940440) »