• Product name

    Anti-HDAC1 antibody - ChIP Grade
    See all HDAC1 primary antibodies
  • Description

    Rabbit polyclonal to HDAC1 - ChIP Grade
  • Host species

  • Tested applications

    Suitable for: ICC/IF, IHC - Wholemount, ChIP, IP, WBmore details
  • Species reactivity

    Reacts with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 503-521 of Fruit fly (Drosophila melanogaster) HDAC1

  • General notes

    The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.



Our Abpromise guarantee covers the use of ab1767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
IHC - Wholemount Use at an assay dependent concentration. PubMed: 22195015
ChIP Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
WB 1/400. Predicted molecular weight: 65 kDa.


  • Function

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.
  • Tissue specificity

    Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
  • Sequence similarities

    Belongs to the histone deacetylase family. HD type 1 subfamily.
  • Post-translational

    Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
    Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
    Ubiquitinated by CHFR, leading to its degradation by the proteasome.
  • Cellular localization

  • Information by UniProt
  • Database links

    • Alternative names

      • DKFZp686H12203 antibody
      • GON 10 antibody
      • HD1 antibody
      • HDAC 1 antibody
      • HDAC1 antibody
      • HDAC1_HUMAN antibody
      • Histone deacetylase 1 antibody
      • Reduced potassium dependency yeast homolog like 1 antibody
      • RPD3 antibody
      • RPD3L1 antibody
      see all


    • Immunohistochemical analysis of whole mount Drosophila melanogaster brain, staining HDAC1 with ab1767, at 1/1000 dilution.


    This product has been referenced in:

    • Panikker P  et al. Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition. J Neurosci 38:4569-4583 (2018). Read more (PubMed: 29654189) »
    • Cabezas-Cruz A  et al. Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis. Epigenetics 11:303-19 (2016). Read more (PubMed: 27019326) »
    See all 12 Publications for this product

    Customer reviews and Q&As

    1-3 of 3 Abreviews or Q&A


    Thank you for your enquiry. This antibody is sold as whole antiserum. The IgG concentration has not been determined. However, I would expect it to be within a range of 10-16mgml-1 given that it is rabbit whole serum. We have not received reviews of this product. Please can you detail where you have seen details of the concentration of this antibody? This antibody has been applied by chromatin IP in the following publication; Breiling A et al. General transcription factors bind promoters repressed by Polycomb group proteins. Nature 412:651-5 (2001). PubMed: 11493924 I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

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    Thank you for your enquiry. All the information that we have regarding ab1767 is located on the online datasheet. Unfortunately, we are not aware of any publications that feature the use of this antibody. To our knowledge, customized protocols are not required for this antibody. For Western blotting, I would suggest starting at a dilution of 1:100. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement.

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