Key features and details
- Rabbit polyclonal to HDAC10
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-HDAC10 antibody
See all HDAC10 primary antibodies
DescriptionRabbit polyclonal to HDAC10
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide, corresponding to amino acids near the N terminus of Human HDAC10.
- Jurkat Cells, Mouse Intestine and Rat Brain for Western blot.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Concentration information loading...
PurityProtein A purified
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab18971 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Tissue specificityUbiquitous. High expression in liver, spleen, pancreas and kidney.
Sequence similaritiesBelongs to the histone deacetylase family. HD type 2 subfamily.
Cellular localizationCytoplasm. Nucleus. Excluded from the nucleoli.
- Information by UniProt
- DKFZP761B039 antibody
- HD 10 antibody
- HD10 antibody
All lanes : Anti-HDAC10 antibody (ab18971) at 2.5 µg/ml
Lane 1 : Jurkat cell lysate (30ug)
Lane 2 : Mouse intestine lysate (30ug)
Lane 3 : Rat brain lysate (30ug)
Predicted band size: 71 kDa
Observed band size: 74 kDa why is the actual band size different from the predicted?
Additional bands at: 55 kDa. We are unsure as to the identity of these extra bands.
ab18971 has been referenced in 2 publications.
- Chi Z et al. Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine ?-lyase protein degradation. Pharmacol Res 146:104281 (2019). PubMed: 31125601
- Liu J et al. Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med 14:7 (2016). Human . PubMed: 26747087