Key features and details
- Rabbit polyclonal to HDAC10
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-HDAC10 antibody
See all HDAC10 primary antibodies
DescriptionRabbit polyclonal to HDAC10
Tested Applications & Species
Application Species WBHuman
Synthetic peptide, corresponding to amino acids near the N terminus of Human HDAC10.
- Jurkat Cells, Mouse Intestine and Rat Brain for Western blot.
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One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol, 1% BSA
Concentration information loading...
PurityProtein A purified
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab18971 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Tissue specificityUbiquitous. High expression in liver, spleen, pancreas and kidney.
Sequence similaritiesBelongs to the histone deacetylase family. HD type 2 subfamily.
Cellular localizationCytoplasm. Nucleus. Excluded from the nucleoli.
- Information by UniProt
- DKFZP761B039 antibody
- HD 10 antibody
- HD10 antibody
All lanes : Anti-HDAC10 antibody (ab18971) at 2.5 µg/ml
Lane 1 : Jurkat cell lysate (30ug)
Lane 2 : Mouse intestine lysate (30ug)
Lane 3 : Rat brain lysate (30ug)
Predicted band size: 71 kDa
Observed band size: 74 kDa why is the actual band size different from the predicted?
Additional bands at: 55 kDa. We are unsure as to the identity of these extra bands.
ab18971 has been referenced in 2 publications.
- Chi Z et al. Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine ?-lyase protein degradation. Pharmacol Res 146:104281 (2019). PubMed: 31125601
- Liu J et al. Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med 14:7 (2016). Human . PubMed: 26747087