Overview

  • Product name

  • Description

    Rabbit polyclonal to HDAC8
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human HDAC8 aa 180-230 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q9BY41

  • Positive control

    • IHC-P: Human brain and mouse pancreas tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
  • Tissue specificity

    Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
  • Sequence similarities

    Belongs to the histone deacetylase family. HD type 1 subfamily.
  • Post-translational
    modifications

    Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.
  • Cellular localization

    Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
  • Information by UniProt
  • Database links

  • Alternative names

    • CDA07 antibody
    • CDLS5 antibody
    • HD 8 antibody
    • HD8 antibody
    • HDAC 8 antibody
    • Hdac8 antibody
    • HDAC8_HUMAN antibody
    • HDACL 1 antibody
    • HDACL1 antibody
    • Histone deacetylase 8 antibody
    • Histone deacetylase like 1 antibody
    • MRXS6 antibody
    • RPD 3 antibody
    • RPD3 antibody
    • WTS antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of mouse pancreas tissue labeling HDAC8 with ab217702 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of human brain tissue labeling HDAC8 with ab217702 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.

References

This product has been referenced in:

  • Ahn MY HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. Oncol Lett 16:6552-6560 (2018). Read more (PubMed: 30405794) »
See 1 Publication for this product

Customer reviews and Q&As

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