Overview

  • Product name

    Helenalin, NF-kappaB inhibitor
  • Description

    NF-κB inhibitor
  • Biological description

    NF-κB inhibitor. Induces apoptosis. Shows anti-inflammatory and antineoplastic effects. Shows hepatoprotective effects in vivo. Orally active.
  • CAS Number

    6754-13-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3aR,5R,5aR,8aR,9S,9aS)-9-Hydroxy-5,8a-dimethyl-1-methylidene-3a,4,5,5a,9,9a-hexahydroazuleno[6,7-b]furan-2,8-dione

  • Molecular weight

    262.30
  • Molecular formula

    C15H18O4
  • PubChem identifier

    23205
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol (up to 10 mg/ml) and in DMSO (up to 20 mg/ml).

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lin X  et al. Helenalin attenuates alcohol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and suppressing HSC activation. Fitoterapia 95:203-13 (2014). Read more (PubMed: 24704336) »
  • Jang JH  et al. Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma. Toxicol In Vitro 27:588-96 (2013). Read more (PubMed: 23123298) »
  • Lyss G  et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem 273:33508-16 (1998). Read more (PubMed: 9837931) »
See all 2 Publications for this product

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