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NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) is a protein encoded by the NLRP3 gene. NLRP3 is expressed predominantly in macrophages and plays a crucial role in innate immunity and inflammation.
NLRP3 is regulated by post-translational modifications, such as ubiquitination and phosphorylation, and has several isoforms. Therefore, several bands may exist in a western blot assay. The predicted molecular weight of NLRP3 is about 118 kDa.
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