Overview

  • Product name

    Anti-Hemoglobin subunit gamma 2 antibody
  • Description

    Rabbit polyclonal to Hemoglobin subunit gamma 2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-97 of Human Hemoglobin subunit gamma 2 (Uniprot ID: P69892).

  • Positive control

    • U87-MG whole cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab153898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 16 kDa.

Target

  • Function

    Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
  • Tissue specificity

    Red blood cells.
  • Involvement in disease

    Defects in HBG2 are the cause of cyanosis transient neonatal (TNCY) [MIM:613977]. TNCY is a disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain.
  • Sequence similarities

    Belongs to the globin family.
  • Developmental stage

    Expressed until four or five weeks after birth.
  • Post-translational
    modifications

    Acetylation of Gly-2 converts Hb F to the minor Hb F1.
  • Information by UniProt
  • Database links

  • Alternative names

    • Abnormal hemoglobin antibody
    • FLJ76540 antibody
    • G gamma globin antibody
    • Gamma 2 globin antibody
    • Gamma-2-globin antibody
    • Hb F Ggamma antibody
    • HBG 2 antibody
    • HBG2 antibody
    • HBG2_HUMAN antibody
    • Hemoglobin gamma 2 chain antibody
    • Hemoglobin gamma G antibody
    • Hemoglobin gamma G chain antibody
    • Hemoglobin gamma-2 chain antibody
    • Hemoglobin gamma-G chain antibody
    • Hemoglobin subunit gamma 2 antibody
    • Hemoglobin subunit gamma-2 antibody
    • Methemoglobin antibody
    • OTTHUMP00000069638 antibody
    see all

Images

  • Anti-Hemoglobin subunit gamma 2 antibody (ab153898) at 1/500 dilution + U87-MG whole cell lysate at 30 µg

    Predicted band size: 16 kDa



    15% SDS PAGE

References

ab153898 has not yet been referenced specifically in any publications.

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