Key features and details
- Mouse monoclonal [10E11] to Hepatitis B Virus Core Antigen
- Suitable for: ICC/IF, WB, IP, ELISA, IHC-P, IHC-Fr
- Reacts with: Hepatitis B virus
- Isotype: IgG1
Product nameAnti-Hepatitis B Virus Core Antigen antibody [10E11]
See all Hepatitis B Virus Core Antigen primary antibodies
DescriptionMouse monoclonal [10E11] to Hepatitis B Virus Core Antigen
This antibody reacts with HBV Core Antigen (amino acid residues 1-10). Ab8639 should recognize both the precoreprotein and core protein.
Ab8639 was raised against serotype ayw but will work with all other genotypes.
Tested applicationsSuitable for: ICC/IF, WB, IP, ELISA, IHC-P, IHC-Frmore details
Species reactivityReacts with: Hepatitis B virus
Purified Denatured Hepatitis B Core Antigen
Epitopeaa positions 1-10
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Concentration information loading...
PurityTissue culture supernatant
Light chain typekappa
Our Abpromise guarantee covers the use of ab8639 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration.|
|ELISA||Use at an assay dependent concentration.|
RelevanceHepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
Cellular localizationCapsid protein: Virion. Host cytoplasm, hepatocyte nucleus.
- C antibody
- Capsid protein antibody
- Core and e antigen antibody
ab8639 has been referenced in 9 publications.
- Pang EL et al. Epitope Presentation of Dengue Viral Envelope Glycoprotein Domain III on Hepatitis B Core Protein Virus-Like Particles Produced in Nicotiana benthamiana. Front Plant Sci 10:455 (2019). PubMed: 31057572
- Yang G et al. HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome. Theranostics 9:7345-7358 (2019). PubMed: 31695772
- Wang J et al. Host Gene SEL1L Involved in Endoplasmic Reticulum-Associated Degradation Pathway Could Inhibit Hepatitis B Virus at RNA, DNA, and Protein Levels. Front Microbiol 10:2869 (2019). PubMed: 31921048
- Liu K et al. Multiple roles of core protein linker in hepatitis B virus replication. PLoS Pathog 14:e1007085 (2018). PubMed: 29782550
- Zhao Q et al. Hepatitis B Virus Core Protein Dephosphorylation Occurs during Pregenomic RNA Encapsidation. J Virol 92:N/A (2018). PubMed: 29669831
- Saunders K & Lomonossoff GP The Generation of Turnip Crinkle Virus-Like Particles in Plants by the Transient Expression of Wild-Type and Modified Forms of Its Coat Protein. Front Plant Sci 6:1138 (2015). PubMed: 26734041
- Peyret H et al. Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins. PLoS One 10:e0120751 (2015). WB . PubMed: 25830365
- Macdonald DC et al. Harnessing alveolar macrophages for sustained mucosal T-cell recall confers long-term protection to mice against lethal influenza challenge without clinical disease. Mucosal Immunol N/A:N/A (2013). PubMed: 23715172
- Bichko V et al. Epitopes recognized by antibodies to denatured core protein of hepatitis B virus. Mol Immunol 30:221-31 (1993). PubMed: 7679466