Key features and details
- Mouse monoclonal [14E11] to Hepatitis B Virus Core Antigen
- Suitable for: ELISA, IHC-FoFr, IHC-Fr, ICC/IF, IP, IHC-P, WB
- Reacts with: Hepatitis B virus
- Isotype: IgG2b
Product nameAnti-Hepatitis B Virus Core Antigen antibody [14E11]
See all Hepatitis B Virus Core Antigen primary antibodies
DescriptionMouse monoclonal [14E11] to Hepatitis B Virus Core Antigen
ab8638 was raised against serotype ayw but will work with all other genotypes.
Tested applicationsSuitable for: ELISA, IHC-FoFr, IHC-Fr, ICC/IF, IP, IHC-P, WBmore details
Species reactivityReacts with: Hepatitis B virus
Purified Denatured Hepatitis B Core Antigen
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferBioreactor harvest, serum-free medium, no protein added
Concentration information loading...
Light chain typekappa
Our Abpromise guarantee covers the use of ab8638 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent concentration.|
|ICC/IF||Use at an assay dependent concentration.|
|IP||Use at an assay dependent concentration.|
RelevanceHepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
Cellular localizationCapsid protein: Virion. Host cytoplasm, hepatocyte nucleus.
- C antibody
- Capsid protein antibody
- Core and e antigen antibody
ab8638 has been referenced in 7 publications.
- Song C et al. Associations Between Hepatitis B Virus Infection and Risk of All Cancer Types. JAMA Netw Open 2:e195718 (2019). PubMed: 31199446
- Xu F et al. NF-?B-Dependent IFIT3 Induction by HBx Promotes Hepatitis B Virus Replication. Front Microbiol 10:2382 (2019). PubMed: 31681236
- Liang P et al. Efficient Humoral and Cellular Immune Responses Induced by a Chimeric Virus-like Particle Displaying the Epitope of EV71 without Adjuvant. Biomed Environ Sci 31:343-350 (2018). WB ; Hepatitis B virus . PubMed: 29866216
- Ye X et al. Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms. J Virol 88:72-81 (2014). PubMed: 24131712
- Gutelius D et al. Characterization of the pleiotropic effects of the genotype g-specific 36-nucleotide insertion in the context of other hepatitis B virus genotypes. J Virol 85:13278-89 (2011). PubMed: 21994450
- Tsai A et al. Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations. Virology 387:364-72 (2009). WB . PubMed: 19327810
- Guarnieri M et al. Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression. J Virol 80:587-95 (2006). PubMed: 16378961