Overview

  • Product name

    Anti-Hepatitis B Virus Core Antigen antibody
    See all Hepatitis B Virus Core Antigen primary antibodies
  • Description

    Rabbit polyclonal to Hepatitis B Virus Core Antigen
  • Host species

    Rabbit
  • Specificity

    Serotype specificity information is not available for this antibody

  • Tested applications

    Suitable for: IHC-P, IHC-Frmore details
  • Species reactivity

    Reacts with: Hepatitis B virus
  • Immunogen

    Full length native protein (purified) corresponding to Hepatitis B Virus Core Antigen.

  • Positive control

    • Human liver tissue infected with Hepatitis B virus.

Properties

Applications

Our Abpromise guarantee covers the use of ab115992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/400.
IHC-Fr 1/200 - 1/400.

Target

  • Relevance

    Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
  • Cellular localization

    Capsid protein: Virion. Host cytoplasm, hepatocyte nucleus.
  • Database links

    • Alternative names

      • C antibody
      • Capsid protein antibody
      • Core and e antigen antibody
      • core antibody
      • Core antigen antibody
      • Core protein antibody
      • HBc antibody
      • HBcAg antibody
      • HBVgp4 antibody
      • Hepatitis B core antigen antibody
      • Hepatitis B Virus core antigen antibody
      • p21.5 antibody
      • precore/core protein antibody
      see all

    References

    This product has been referenced in:

    • Liu J  et al. Pathological Pattern of Intrahepatic HBV in HCC is Phenocopied by PDX-Derived Mice: a Novel Model for Antiviral Treatment. Transl Oncol 12:1138-1146 (2019). Read more (PubMed: 31202090) »
    • Corcuera A  et al. Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro. Antiviral Res 158:135-142 (2018). Read more (PubMed: 30031759) »
    See all 4 Publications for this product

    Customer reviews and Q&As

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    Application
    Western blot
    Sample
    Human Cell lysate - whole cell (Primary Human Hepatocytes (PHH))
    Gel Running Conditions
    Reduced Denaturing (Precast 4-20%)
    Loading amount
    30 µg
    Specification
    Primary Human Hepatocytes (PHH)
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 20°C

    Mr. Thomas Lahlali

    Verified customer

    Submitted Mar 22 2018

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