Overview

  • Product name

    Anti-Hepatitis B Virus Surface Antigen antibody [HB3]
    See all Hepatitis B Virus Surface Antigen primary antibodies
  • Description

    Mouse monoclonal [HB3] to Hepatitis B Virus Surface Antigen
  • Host species

    Mouse
  • Specificity

    Recognizes following Hepatitis B virus subtypes:ayw2, ayw3, ayw4, ayr, adw2, adw4, adrq+, adrq-. Specificity of MAb HB3 was verified by ELISA on panel of International Workshop on HBsAg Subtypes (Paris, April 1975). This antibody does not cross-block with ab8333 and is therefore suitable for use with ab8333 as a matched pair.
  • Tested applications

    Suitable for: ELISA, ICCmore details
  • Species reactivity

    Reacts with: Hepatitis B virus
  • Immunogen

    Full length native protein (purified from human plasma).

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.097% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Proprietary Purification
  • Purification notes

    Purified from TCS. Purified by precipitation and chromatography. Purity >95% by SDS-PAGE.
  • Clonality

    Monoclonal
  • Clone number

    HB3
  • Myeloma

    unknown
  • Isotype

    IgG1
  • Light chain type

    unknown
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab8256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
ICC Use at an assay dependent dilution.

Target

  • Relevance

    Hepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
  • Cellular localization

    Virion membrane
  • Database links

    • Alternative names

      • Large envelope protein antibody
      • Large surface protein antibody
      • LHB antibody
      • Major surface antigen antibody

    References

    ab8256 has not yet been referenced specifically in any publications.

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