• Product name
    Anti-Hepatitis B Virus Surface Antigen antibody [S 26]
    See all Hepatitis B Virus Surface Antigen primary antibodies
  • Description
    Mouse monoclonal [S 26] to Hepatitis B Virus Surface Antigen
  • Host species
  • Tested applications
    Suitable for: ELISA, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Hepatitis B virus
  • Immunogen

    Full length native protein (purified).

  • Epitope
    Amino acids 132-137 of pre-S.



Our Abpromise guarantee covers the use of ab18797 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution.
    Immunofluorescent and immunoperoxidase staining of infected liver tissues and HBV-transfected hepatoma cells, immunoelectron microscopy.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Hepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
    • Cellular localization
      Virion membrane
    • Database links
      • Alternative names
        • Large envelope protein antibody
        • Large surface protein antibody
        • LHB antibody
        • Major surface antigen antibody


      ab18797 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      1-3 of 3 Abreviews or Q&A


      Virtually all anti-HBsAg mabs (including this one) are conformation-specific, i.e., they recognize only native antigen. That's why they do not work usually neither in WB nor in denaturing ELISA. ab18797 will work in both of those assays, but only the HBsAg-L or HBsAg-M (not HBsAg-S) antigens will be recognized. For both S14 and S26 mabs the total HBsAg purified from pooled HBV+ serum was used as immunogen. Both ad and ay subtypes are recognized. ab8636- suitable protein controls should be ab73741 or ab91277.

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      I have received feedback from the laboratory saying "Your customer is doing everything right, the dilution is 1 to 1000 and 5% dry milk for 1 hour blocking is what we recommend. At this point we can only assume that something happened to product in transit". Since you stated that your samples definitely contain the pre-S2 region as detected by PCR I would like to offer you a replacement vial, if you can please provide your order details? I look forward to hearing from you regarding your order information,

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      Thank you very much for contacting us. I just wanted to let you know that I am still working on your enquiry. I have contacted the originator of this antibody for the information you requested, and am awaiting a reply. I'm very sorry for the delay. I will forward to you the information as soon as I receive it. My apologies for the inconvenience, and thank you for your patience.

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