Anti-Hepatitis C Virus antibody (ab1035)

Submit a review Q&A (1)References (2)

Overview

  • Product name
    Anti-Hepatitis C Virus antibody
    See all Hepatitis C Virus primary antibodies
  • Description
    Rabbit polyclonal to Hepatitis C Virus
  • Host species
    Rabbit
  • Specificity
    This antibody reacts with the 44 kD core protein C3, the envelope protein, and E2 (NS1) of Hepatitis C Virus.
  • Tested applications
    Suitable for: WBmore details
  • Immunogen

    Peptide corresponding to amino acids 33-43 of Hepatitis C Virus (HCV) core protein C3.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.05% Sodium azide
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    unknown
  • Light chain type
    unknown
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab1035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000.

Target

  • Relevance
    Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha.
  • Cellular localization
    Virus surface
  • Alternative names
    • Genome polyprotein antibody
    • HCV antibody
    • Hepatitis C virus polyprotein antibody

References

This product has been referenced in:
  • Munjal C  et al. TGF-ß mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Dis Model Mech 7:987-96 (2014). IHC . Read more (PubMed: 25056700) »
  • Yuk CS  et al. Development and evaluation of a protein microarray chip for diagnosis of hepatitis C virus. Biotechnol Lett 26:1563-8 (2004). Read more (PubMed: 15604797) »
See all 2 Publications for this product

Publishing research using ab1035? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

I am searching for an antibody to Hepatitis C strain 2a for use with Western blotting. I see that you have several HCV antibodies but could only find information regarding which strain they were raised against for a few. An HCV core protein antibody may be suitable from another strain if it can be used in Western blotting assays but one specifically raised against strain 2a would be best. I would appreciate any further information you might be able to provide and thank you in advance for your time and consideration.

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Answer

Thank you for your enquiry. I looked up some Hepatitis C Virus antibodies that may be of interest to you and the information is listed below. It does not appear that we have one that is specific for strain 2a or has even bee tested for reactivity with that strain. Please contact us again if you have any additional questions. Ab20773 - Goat polyclonal to Hepatitis C Virus NS5: Immunogen used was recombinant NS5 a&b genotype 1a (100% of a and 70% of b). This antibody has not been tested for reactivity to genotype 2a. Ab1035 - Rabbit polyclonal to Hepatitis C Virus: Immunogen used was a peptide corresponding to amino acids 33-43 of Hepatitis C Virus (HCV) core protein C3. Ab1033 - Rabbit polyclonal to Hepatitis C Virus: Immunogen used was a peptide corresponding to amino acids 9-21 of Hepatitis C Virus (HCV) core protein C1. For ab1035 and ab1033, strain 2a hasn't been tested, but the understanding is that the sequences derived from core proteins C1 and C3 which were used for immunization are well conserved in the different strains of Hepatitis C virus. Therefore, it is likely that these antibodies will react with Hepatitis C strain 2a. Ab18662 - Mouse monoclonal [24-8 ] to Hepatitis C Virus: Immunogen used was a highly antigenic polypeptide consisting of essential sequences of at least 60 residues in length, which were selected from genes encoding the NS-3 region of Chinese HCV strains. This antibody is not hepatitis C virus[HCV] strain specific, and will recognize the NS3 of HCV strains. If the NS3 variation has been observed in this strain, it may cause the weaker/or non reaction when using this antibody, in the case of the variation is matched the epitope region or interfered the Antibody-Antigen binding-reaction site/sequences. Ab27791 - Goat polyclonal to Hepatitis C Virus: Immunogen used was recombinant chimeric HCV polyprotein (60 kDa). This antibody product will react with various HCV, and the reaction is not HCV strain specific.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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