Anti-Hepatitis C Virus Core Antigen antibody [6A1] (ab2582)
Key features and details
- Mouse monoclonal [6A1] to Hepatitis C Virus Core Antigen
- Suitable for: ELISA, IP
- Reacts with: Hepatitis C virus
- Isotype: IgG2a
Related conjugates and formulations
Overview
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Product name
Anti-Hepatitis C Virus Core Antigen antibody [6A1]
See all Hepatitis C Virus Core Antigen primary antibodies -
Description
Mouse monoclonal [6A1] to Hepatitis C Virus Core Antigen -
Host species
Mouse -
Specificity
This antibody is specific for Hepatitis C Core Antigen. -
Tested applications
Suitable for: ELISA, IPmore details -
Species reactivity
Reacts with: Hepatitis C virus -
Immunogen
Recombinant fragment, corresponding to amino acids 2-80 of Hepatitis C Virus Core Antigen
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Epitope
This antibody recognises amino acid residues 1-80 of Hepatitis C Core Antigen. -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide -
Concentration information loading...
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Clonality
Monoclonal -
Clone number
6A1 -
Myeloma
unknown -
Isotype
IgG2a -
Light chain type
unknown -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab2582 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
1/10000.
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|
IP |
Use at an assay dependent concentration.
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Notes |
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ELISA
1/10000. |
IP
Use at an assay dependent concentration. |
Target
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Relevance
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients. -
Cellular localization
Endoplasmic reticulum -
Database links
- SwissProt: P26664 Hepatitis C virus
- SwissProt: P29846 Hepatitis C virus
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Alternative names
- Core protein p21 antibody
- HCV core antigen antibody
- HCV core protein antibody
- Hepatitis C Virus core protein antibody
Datasheets and documents
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Datasheet download
References (1)
ab2582 has been referenced in 1 publication.
- Draz MS et al. Virus detection using nanoparticles and deep neural network-enabled smartphone system. Sci Adv 6:N/A (2020). PubMed: 33328239