• Product name
    Anti-Hepatitis C Virus Core Antigen antibody
    See all Hepatitis C Virus Core Antigen primary antibodies
  • Description
    Goat polyclonal to Hepatitis C Virus Core Antigen
  • Host species
  • Specificity
    Ab50288 is specific for the core regions of Hepatitis C virus.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Hepatitis C virus
  • Immunogen

    Hepatitis C virus (HCV) recombinant full length core (genotype 1a).



Our Abpromise guarantee covers the use of ab50288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 21 kDa.
ELISA Use at an assay dependent dilution.


  • Relevance
    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localization
    Endoplasmic reticulum
  • Database links
    • Alternative names
      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody


    ab50288 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    1-4 of 4 Abreviews or Q&A


    Thank you for contacting Abcam.

    For ab50288, you get 200ug at 5mg/ml of product, not 200ul. You should have received a total of 40ul of solution in the vial that was sent to you. When you first received the antibody, did you spin the vial down before opening it? As sometimes liquid gets trapped in the cap and a brief centrifuge will help recover the total volume.

    You say in the original message that you got ˜20ul of liquid, would it be possible to spin the vial and then re-measure the volume present. If it is still short after that, then I would be happy to send you a new vial of antibody.

    If there is anything else I can help you with, please let me know.

    Read More


    Thank you for your patience.

    Yes, I can confirm that the full-length core was used as immunogen to raise this antibody.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More


    Thank you for contacting us.

    I received the following response from the lab:

    This antibody was raised against the recombinant core of HCV and is specific for the core.

    I am inquiring with them about more details regarding full length or fraction of the core, as this was not addressed in their reply.

    Thank you for your patience!

    Read More


    Thank you for contacting us. ab20404 and ab50288 are both goat polyclonals antibodies against Hepatitis C Virus Core 1a. They have both been used with Western blotting and ELISA, and ab50288 has been used with IHC. Whilst ab20404 is at a concentration of 4.0 mg/ml and has been purified by Sodium sulfate precipitation and ion-exchange chromatography, ab50288 is provided at a concentration of 5.0 mg/ml and has been purified by protein A affinity purification. These antibodies are very similar. We sometimes stock similar items to ensure that if one of the antibodies becomes unavailable we have an alternative available to offer to our customers. Depending on your application both ab20404 and ab50288 should be applicable. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    For licensing inquiries, please contact partnerships@abcam.com

    Sign up