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  1. Link

    hepatitis-c-virus-core-antigen-antibody-ab58713.pdf

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Microbiology Organism Virus RNA Virus ssRNA positive strand virus HCV
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Anti-Hepatitis C Virus Core Antigen antibody (ab58713)

  • Datasheet
  • SDS
Reviews (1)Q&A (1)References (5)

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Key features and details

  • Rabbit polyclonal to Hepatitis C Virus Core Antigen
  • Suitable for: WB, ELISA
  • Reacts with: Hepatitis C virus
  • Isotype: IgG

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Overview

  • Product name

    Anti-Hepatitis C Virus Core Antigen antibody
    See all Hepatitis C Virus Core Antigen primary antibodies
  • Description

    Rabbit polyclonal to Hepatitis C Virus Core Antigen
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Hepatitis C virus
  • Immunogen

    Synthetic peptide corresponding to N-terminal residues of Hepatitis C virus core protein.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • HCV
    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • Hepatitis A/C/E/G

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab58713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA
Use at an assay dependent concentration.
Notes
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA
Use at an assay dependent concentration.

Target

  • Relevance

    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localization

    Endoplasmic reticulum
  • Database links

    • SwissProt: P26664 Hepatitis C virus
    • SwissProt: P29846 Hepatitis C virus
    • Alternative names

      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    Protocols

    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (5)

    Publishing research using ab58713? Please let us know so that we can cite the reference in this datasheet.

    ab58713 has been referenced in 5 publications.

    • Galasso M  et al. Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion. Nat Commun 10:481 (2019). PubMed: 30696822
    • Anticoli S  et al. Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures. Oxid Med Cell Longev 2019:6452390 (2019). PubMed: 30906503
    • Venkatesh AG  et al. Clinical detection of Hepatitis C viral infection by yeast-secreted HCV-core:Gold-binding-peptide. Biosens Bioelectron 119:230-236 (2018). PubMed: 30144754
    • Granato M  et al. HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2. Sci Rep 6:30649 (2016). WB ; Human . PubMed: 27476557
    • Smirnova OA  et al. Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. Oxid Med Cell Longev 2016:8341937 (2016). PubMed: 27200149

    Customer reviews and Q&As

    Show All Reviews Q&A
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    1-2 of 2 Abreviews or Q&A

    Immunocytochemistry/ Immunofluorescence abreview for Anti-Hepatitis C Virus Core Antigen antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Blocking step
    BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Sample
    Human Cell (human hepatocytes (Huh-7 cells))
    Specification
    human hepatocytes (Huh-7 cells)
    Permeabilization
    No
    Fixative
    1:1 Methanol-acetone
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    DR. Nicole Corder

    Verified customer

    Submitted Jun 19 2014

    Question

    Please provide C of A ‘s for the following



    ab39716 lot *
    ab8637 lot G*

    ab49013 lot*

    ab58713 lot G*


    Read More

    Abcam community

    Verified customer

    Asked on Oct 01 2012

    Answer

    Thank you for contacting Abcam.
    Please find attached the requested Certificates of Analysis.
    If there is anything else I can help you with, please let me know.

    Read More

    Abcam Scientific Support

    Answered on Oct 01 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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