• Product name
    Anti-Hepatitis C Virus Core Antigen antibody [B3314M]
    See all Hepatitis C Virus Core Antigen primary antibodies
  • Description
    Mouse monoclonal [B3314M] to Hepatitis C Virus Core Antigen
  • Host species
  • Specificity

    HCV Core Antigen (Amino Acids 70-90).

  • Tested applications
    Suitable for: ELISA, WB, IHC-Frmore details
  • Immunogen

    Recombinant fragment corresponding to Hepatitis C Virus Core Antigen aa 70-90. (Genotype 1b).

  • Positive control
    • IHC-Fr: Liver tissue.



Our Abpromise guarantee covers the use of ab252694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

(~10-6 )

WB 1/1000.
IHC-Fr 1/20.


  • Relevance
    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localization
    Endoplasmic reticulum
  • Alternative names
    • Core protein p21 antibody
    • HCV core antigen antibody
    • HCV core protein antibody
    • Hepatitis C Virus core protein antibody


ab252694 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab252694.
Please use the links above to contact us or submit feedback about this product.

For licensing inquiries, please contact partnerships@abcam.com

Sign up