Key features and details
- Mouse monoclonal [H21] to Hepatitis C Virus Core Antigen
- Suitable for: IHC-P, ELISA
- Reacts with: Hepatitis C virus
- Isotype: IgG1
Product nameAnti-Hepatitis C Virus Core Antigen antibody [H21]
See all Hepatitis C Virus Core Antigen primary antibodies
DescriptionMouse monoclonal [H21] to Hepatitis C Virus Core Antigen
SpecificityHepatitis C Virus antigen core.
Tested applicationsSuitable for: IHC-P, ELISAmore details
Species reactivityReacts with: Hepatitis C virus
Recombinant full length protein (expressed in E. coli).
EpitopeAmino acids 70-90
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.1% Sodium azide
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab13829 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50. Tested using paraffin-embedded liver sections from HCV patients.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Cellular localizationEndoplasmic reticulum
- Core protein p21 antibody
- HCV core antigen antibody
- HCV core protein antibody
- Hepatitis C Virus core protein antibody
ab13829 has not yet been referenced specifically in any publications.