Key features and details
- Goat polyclonal to Hepatitis C Virus Core NS3 + NS4
- Suitable for: IHC-Fr, WB, ELISA
- Reacts with: Hepatitis C virus
- Isotype: IgG
Product nameAnti-Hepatitis C Virus Core NS3 + NS4 antibody
DescriptionGoat polyclonal to Hepatitis C Virus Core NS3 + NS4
Tested applicationsSuitable for: IHC-Fr, WB, ELISAmore details
Species reactivityReacts with: Hepatitis C virus
Recombinant full length protein - polypeptide containing Hepatitis C Virus Core, NS3 + NS4
This antibody recognises Hepatitis C Virus Core NS3 + NS4 in viral and infected tissue samples.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS
Concentration information loading...
Primary antibody notesThis antibody recognises Hepatitis C Virus Core NS3 + NS4 in viral and infected tissue samples.
Our Abpromise guarantee covers the use of ab68632 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use at an assay dependent dilution.|
RelevanceHCV is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural protein necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. The NS3 serine proteinase (NS3P) is a non-structural hepatitis C protein responsible for proteolytic processing of other non-structural proteins; because of this, it is also the most extensively studied protein of the Hepatitis C genome.
Cellular localizationEndoplasmic reticulum and Mitochondrial
- helicase NS3 antibody
- Non structural protein 4A antibody
- Non structural protein 4B antibody
ab68632 has been referenced in 1 publication.
- Zhang MQ et al. Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135. Front Immunol 9:2176 (2018). PubMed: 30319633