Overview

  • Product name

    Anti-Hepatitis C Virus Core NS3 + NS4 antibody
  • Description

    Goat polyclonal to Hepatitis C Virus Core NS3 + NS4
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-Fr, WB, ELISAmore details
  • Species reactivity

    Reacts with: Hepatitis C virus
  • Immunogen

    Recombinant full length protein - polypeptide containing Hepatitis C Virus Core, NS3 + NS4

  • General notes


    This antibody recognises Hepatitis C Virus Core NS3 + NS4 in viral and infected tissue samples.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 0.0268% PBS
  • Concentration information loading...
  • Purity

    Affinity purified
  • Primary antibody notes

    This antibody recognises Hepatitis C Virus Core NS3 + NS4 in viral and infected tissue samples.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab68632 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent dilution.
WB 1/1000.
ELISA 1/6000.

Target

  • Relevance

    HCV is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural protein necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. The NS3 serine proteinase (NS3P) is a non-structural hepatitis C protein responsible for proteolytic processing of other non-structural proteins; because of this, it is also the most extensively studied protein of the Hepatitis C genome.
  • Cellular localization

    Endoplasmic reticulum and Mitochondrial
  • Database links

    • Alternative names

      • helicase NS3 antibody
      • Non structural protein 4A antibody
      • Non structural protein 4B antibody
      • NS3P antibody
      • NS4A antibody
      • NS4B antibody
      • NTPase antibody
      • p27 antibody
      • p70 antibody
      • p8 antibody
      • Serine protease antibody
      see all

    References

    This product has been referenced in:

    • Zhang MQ  et al. Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135. Front Immunol 9:2176 (2018). Read more (PubMed: 30319633) »
    See 1 Publication for this product

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