Key features and details
- Goat polyclonal to Hepatitis C Virus E1
- Suitable for: ELISA, WB, ICC/IF
- Reacts with: Hepatitis C virus
- Isotype: IgG
Product nameAnti-Hepatitis C Virus E1 antibody
See all Hepatitis C Virus E1 primary antibodies
DescriptionGoat polyclonal to Hepatitis C Virus E1
Tested applicationsSuitable for: ELISA, WB, ICC/IFmore details
Species reactivityReacts with: Hepatitis C virus
Recombinant Hepatitis C Virus E1 (genotype 1a).
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.1% Sodium azide
Concentration information loading...
PurityIon Exchange Chromatography
Purification notesab110972 is >95% pure by Sodium sulfate precipitation and ion exchange chromatography.
Our Abpromise guarantee covers the use of ab110972 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent dilution. Reacts with genotype 1a.|
|WB||Use at an assay dependent dilution. Predicted molecular weight: 23 kDa. Reacts with genotypes 1b and 2a.|
|ICC/IF||Use at an assay dependent dilution. Reacts with genotype 1b, but does not react with genotype 2a.|
RelevanceEnvelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
Cellular localizationEndoplasmic reticulum membrane; Single-pass type I membrane protein
- E1 protein antibody
- Envelope glycoprotein E1 antibody
- Gp32 antibody
ab110972 has not yet been referenced specifically in any publications.