Key features and details
- Goat polyclonal to Hepatitis C Virus genotype 1a NS5
- Suitable for: IHC-P, WB, ELISA
- Reacts with: Hepatitis C virus
- Isotype: IgG
Product nameAnti-Hepatitis C Virus genotype 1a NS5 antibody
DescriptionGoat polyclonal to Hepatitis C Virus genotype 1a NS5
Tested applicationsSuitable for: IHC-P, WB, ELISAmore details
Species reactivityReacts with: Hepatitis C virus
Recombinant NS5 a&b genotype 1a (100% of a and 70% of b).
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS
Concentration information loading...
PurityIon Exchange Chromatography
Purification notesAb20773 is purifed by sodium sulfate precipitation and ion-exchange chromatography (>95% pure).
Our Abpromise guarantee covers the use of ab20773 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
RelevanceHepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B (non-structural protein 5B) is an RNA-dependant RNA polymerase responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV.
Cellular localizationEndoplasmic reticulum membrane
- HCV 1a NS5 antibody
- Hepatitis C virus NS5A antibody
- Non-structural protein 5A antibody
- p56 antibody
ab20773 has been referenced in 1 publication.
- Tesfaye A et al. Chimeric mouse model for the infection of hepatitis B and C viruses. PLoS One 8:e77298 (2013). IHC-P . PubMed: 24155939